Paper 2025/089 Original: eprint.iacr.org/2025/089 ↗

An Introduction to Protein Cryptography

Abstract

We introduce protein cryptography, a recently proposed method that encodes data into the amino acid sequences of proteins. Unlike traditional digital encryption, this approach relies on the inherent diversity, complexity, and replication resistance of biological macromolecules, making them highly secure against duplication or tampering. The experimental realization of protein cryptography remains an open problem. To accelerate experimental progress in this area, we provide an accessible and self-contained introduction to the fundamentals of cryptography for biologists with limited mathematical and computational backgrounds. Furthermore, we outline a framework for encoding, synthesizing, and decoding information using proteins. By enabling biologists to actively engage in the development of protein cryptography, this work bridges disciplinary boundaries and paves the way for applications in secure data storage.